Overexpression of apelin in Wharton’ jelly mesenchymal stem cell reverses insulin resistance and promotes pancreatic β cell proliferation in type 2 diabetic rats
نویسندگان
چکیده
منابع مشابه
Impact of Magnesium Deficiency on Pancreatic β-Cell Function in Type 2 Diabetic Nigerians
Objective: Pancreatic b-cell dysfunction is described to be present at the diagnosis of type 2 diabetes mellitus (T2DM) and progressively deteriorated with disease duration. However, its progression is variable and potentially influenced by several factors. The Magnesium (Mg) deficiency mediates insulin resistance but reports regarding its role in pancreatic β-cell dysfunction are scarce and co...
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Objective(s): Increasing evidence suggests that regular physical exercise improves type 2 diabetes mellitus (T2DM). However, the potential beneficial effects of swimming on insulin resistance and lipid disorder in T2DM, and its underlying mechanisms remain unclear. Materials and Methods: Rats were fed with high fat diet and given a low dosage of Streptozotocin (STZ) to induce T2DM model, and su...
متن کاملThe effects of umbilical cord Wharton jelly derived mesenchymal stem cells injection on diabetic wound healing in male rats
Background: The number of patients suffering from diabetic ulcers has been increased in recent years and the current therapies have faced failure. This study aimed to investigate the effects of Wharton’s jelly stem cells (WJMSCs) on the diabetic wound in an animal mode. Methods: During this laboratory experimental study carried out in Skin and Stem Cells Research Center from March 2021 to Nove...
متن کاملEffects of High Intensity Interval Training and Combined Training on Serum Apelin Levels and pancreatic β-cell function in Overweight Type 2 Diabetes Women
Objective: Physical exercise is a well-established therapeutic method in type 2 diabetes treatment. The purpose of this study was to investigate the effects of eight weeks combined and High Intensity Interval Training on serum apelin levels and pancreatic β-cell function in overweight women with type 2 diabetes mellitus. Materials and Methods: Fifty-two overweight female patients with type 2 d...
متن کاملEffects of insulin-like growth factor-induced Wharton jelly mesenchymal stem cells toward chondrogenesis in an osteoarthritis model
Objective(s): This study aimed to determine the collagen type II (COL2) and SOX9 expression in interleukin growth factor (IGF-1)-induced Wharton’s Jelly mesenchymal stem cells (WJMSCs) and the level of chondrogenic markers in co-culture IGF1-WJMSCs and IL1β-CHON002 as osteoarthritis (OA) cells model. Materials and Methods: WJMSCs were induced with IGF1 (75, 150, and 300 ng/ml) to enhance their ...
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ژورنال
عنوان ژورنال: Stem Cell Research & Therapy
سال: 2018
ISSN: 1757-6512
DOI: 10.1186/s13287-018-1084-x